Figure 1.

Localization and effect of a variant identified in the recent genome-wide association study of migraine in synaptic transmission, together with the previously known mutations in familial hemiplegic migraine (FHM: genes are FHM1, CACNA1A; FHM2, ATP1A2; FHM3, SCN1A). The asterisk indicates the excitatory amino acid transporter 2 (EAAT2/GLT-1) recently linked to migraine. Glu, glutamate; FHM1-3, products of genes reported for familial hemiplegic migraine; mGluR, metabolic glutamate receptor. Black dots indicate the accumulation of the neurotransmitter glutamate in the synaptic cleft.