Table 3.
Functional SNPs associated with ischemic stroke
| System | Gene | Polymorphism | References |
|---|---|---|---|
| Lipid metabolism | APOA5 (*606368) | g.-1131T > C, c.1259T > C, c.56C > G, c.IVS3+476G > A | [82-88] |
| APOCIII (*107720) | g.-2854T > G, g.-455C > T, g.-482C > T, c.3238C > G | [73-76] | |
| LPL (*609708) | p.Asn291Ser | [92-95] | |
| GCKR (*600842) | c.1337C > T | [104] | |
| MLXIPL (*605678) | rs17145738, rs3812316 | [105] | |
| GALNT (*602274) | rs4846914 | [104] | |
| Signal transduction | PDE4D (*600129) | Six SNPs, haplotypes | [96-100] |
| Inflammation | ALOX5AP (*603700) | Seven SNPs, haplotypes | [97,100-103] |
ALOX5AP, arachidonate 5-lipoxygenase-activating protein; APOA5, apolipoprotein A5; APOCIII, apolipoprotein CIII; LPL, lipoprotein lipase; PDE4D, phosphodiesterase 4D.