Table 4.
Genome-wide association studies on stroke
| Positive association | ||||||||
|---|---|---|---|---|---|---|---|---|
| Population | Sample size | Sample size in replication | Number of SNPs examined | Number of SNPs examined in replication | Gene | Variant | Platform | References |
| Caucasian | 1164 cases, 18438 controls | 3656 cases, 3,613 controls | 2,194,468 | 2 | Near NINJ2 and WNK1 | rs11833579, rs12425791 | Affymetrix, Illumina | [111] |
| Japanese | 992 cases, 5349 controls | 705 cases, 3,426 controls | 520,000 | 100 | CELSR1 (*604523) | rs6007897, rs4044210 | Affymetrix | [110] |
| Caucasian | 1,661 cases, 10,815 controls | 2,224 cases, 2,583 controls or 2,327 cases, 16,760 controls | 310,881 | 120 | Near PITX2 (*601542) | rs2200733, rs10033464 | Illumina | [107] |
| US | 249 cases, 268 controls | - | 408,000 | - | IMPA2 (*605922), KCNIP4 (*608182), KCNK17 (*607370) | rs7506045 | Illumina | [106] |
CELSR1, cadherin EGF LAG seven-pass G-type receptor 1; IMPA2, inositol(myo)-1(or 4)-monophosphatase 2; KCNIP4, Kv channel interacting protein 4; KCNK17, potassium channel, subfamily K, member 17; NINJ2, Nerve injury-induced protein 2; PITX2, paired-like homeodomain 2.