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Photomicrographs from Lo-MYC mouse at 4 weeks of age. (A) H&E showing 2 populations of acini. Left shows normal histology; right shows high-grade PIN. (B) Immunohistochemical staining for MYC shows that morphologically transformed cells all stain positively. (C) Prostatic intraepithelial neoplasia cells show reduced Nkx3.1 protein staining. 200x.
