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Schematic of the Crk family of adaptor proteins. Common protein interacting domains of the Crk proteins are indicated in comparison with Src. Gag refers to the group-specific antigen encoded by the CT10 avian retrovirus. Y527 in Src, Y221 in CrkII, and Y207 in CrkL are regulatory tyrosine motifs that bind intramolecularly to the SH2 domain.
