Fig. 4.

Effects of transgenic resistin on oral glucose tolerance test in young and old transgenic rats (♦, solid lines) and respective control rats (■, dotted lines). A: glucose concentrations after glucose loading were modestly increased in young transgenic rats compared with age-matched control rats at 30 and 60 min after glucose loading. B: insulin concentrations after glucose loading were similar in young transgenic rats and age-matched control rats. C: glucose concentrations after glucose loading were markedly increased in old transgenic rats compared with age-matched control rats. D: insulin concentrations after glucose loading were significantly increased in old transgenic rats compared with age-matched control rats. *P < 0.05, **P < 0.001.