Table 7.
List of genes upregulated in the pulmonary arteries of 2 mo old hypoxic male SERT+ mice compared with 2 mo old hypoxic male wild-type mice, arranged by biological process
| Gene Symbol | Gene Name | Accession No. | Fold Change | False Discovery Rate |
|---|---|---|---|---|
| Transport | ||||
| LBP | lipopolysaccharide binding protein | scl20002.16.7_10 | 1.92 | 0.019 |
| LTF | lactotransferrin | NM_008522.2 | 6.63 | 0.000 |
| APOC1 | apolipoprotein C-I | NM_007469.2 | 1.95 | 0.020 |
| SLC4A1 | solute carrier family 4 | NM_011403.1 | 2.28 | 0.004 |
| HBB-B1 | hemoglobin, beta adult major chain | NM_008220.2 | 3.05 | 0.032 |
| ABCC9 | ATP-binding cassette, sub-family C | scl0001165.1_35 | 2.25 | 0.015 |
| SLC1A3 | solute carrier family 1 | NM_148938.2 | 1.85 | 0.011 |
| LCN2 | lipocalin 2 | NM_008491.1 | 1.65 | 0.021 |
| Signal Transduction, Protein Binding | ||||
| FGL1 | fibrogen-like protein 1 | scl34887.7.1_10 | 2.48 | 0.007 |
| ANGPTL4 | angiopoietin-like 4 | scl50042.7_106 | 1.89 | 0.019 |
| TNC | tenascin C | scl0002731.1_70 | 1.77 | 0.018 |
| Immune Response | ||||
| CCL7 | chemokine | scl41159.3.1_10 | 2.02 | 0.014 |
| CFD | complement factor D | NM_013459.1 | 1.78 | 0.042 |
| CCL2 | chemokine | scl020296.2_11 | 2.03 | 0.014 |
| CLEC4D | C-type lectin domain family 4, member d | scl017474.5_5 | 1.54 | 0.034 |
| C3 | complement component 3 | scl49743.39.1_15 | 1.74 | 0.042 |
| C1S | complement component 1, s subcomponent | NM_144938.1 | 3.34 | 0.003 |
| PRG4 | PREDICTED: proteoglycan 4 | scl000882.1_25 | 2.34 | 0.003 |
| SPON2 | spondin 2, extracellular matrix protein | NM_133903.2 | 1.98 | 0.019 |
| CXCL14 | chemokine | scl43911.4.1_38 | 1.52 | 0.031 |
| Proteolysis | ||||
| DPEP2 | dipeptidase 2 | scl34381.6_178 | 1.40 | 0.047 |
| CTSK | cathepsin K | NM_007802.2 | 1.56 | 0.014 |
| CFD | complement factor D | NM_013459.1 | 1.78 | 0.042 |
| CPXM1 | carboxypeptidase X 1 | NM_019696.1 | 1.25 | 0.020 |
| CTSC | cathepsin C | NM_009982.2 | 1.75 | 0.020 |
| C1S | complement component 1, s subcomponent | NM_144938.1 | 3.34 | 0.003 |
| HP | haptoglobin | NM_017370.1 | 3.13 | 0.002 |
| Cell Adhesion | ||||
| CNTN2 | contactin 2 | scl0021367.1_277 | 2.19 | 0.017 |
| CPXM1 | carboxypeptidase X 1 | NM_019696.1 | 1.25 | 0.020 |
| COL8A2 | collagen, type VIII, alpha 2 | scl24964.1.1958_52 | 1.98 | 0.018 |
| CYR61 | cysteine rich protein 61 | NM_010516.1 | 1.66 | 0.039 |
| TNC | tenascin C | scl0002731.1_70 | 1.77 | 0.018 |
| SPP1 | secreted phosphoprotein 1 | NM_009263.1 | 2.51 | 0.006 |
| SPON2 | spondin 2, extracellular matrix protein | NM_133903.2 | 1.98 | 0.019 |
| COMP | cartilage oligomeric matrix protein | scl33728.21.1_0 | 1.85 | 0.025 |
| FN1 | fibronectin 1 | scl16639.44.189_5 | 1.57 | 0.013 |
| Apoptosis | ||||
| CIDEC | cell death-inducing DFFA-like effector c | NM_178373.2 | 1.90 | 0.046 |
| COMP | cartilage oligomeric matrix protein | scl33728.21.1_0 | 1.85 | 0.025 |
| Lipid Metabolic Process | ||||
| SLC27A3 | solute carrier family 27 | scl21918.10.1_222 | 1.74 | 0.031 |
| LPL | lipoprotein lipase | scl0016956.1_234 | 1.71 | 0.018 |
| Innate Immune Response | ||||
| LBP | lipopolysaccharide binding protein | scl20002.16.7_10 | 1.92 | 0.019 |
| CFD | complement factor D | NM_013459.1 | 1.78 | 0.042 |
| C3 | complement component 3 | scl49743.39.1_15 | 1.74 | 0.042 |
| C1S | complement component 1, s subcomponent | NM_144938.1 | 3.34 | 0.003 |
| Brown Fat Cell Differentiation | ||||
| ADIPOQ | adiponectin, C1Q and collagen domain containing | scl49310.3_131 | 2.30 | 0.003 |
| LRG1 | leucine-rich alpha-2-glycoprotein 1 | NM_029796.2 | 2.31 | 0.004 |
| Skeletal System Development | ||||
| RUNX1 | runt related transcription factor 1 | scl48188.1.1_190 | 2.07 | 0.011 |
| COL1A1 | procollagen, type I, alpha 1 | scl012842.26_28 | 2.15 | 0.007 |
| Blood Vessel Development | ||||
| COL3A1 | procollagen, type III, alpha 1 | NM_009930.1 | 1.57 | 0.039 |
| COL1A1 | procollagen, type I, alpha 1 | scl012842.26_28 | 2.15 | 0.007 |