Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 May 9;208(5):961–972. doi: 10.1084/jem.20101629

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 Dees et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 4. — 5-HT exerts its profibrotic effects via activation of TGF-β/Smad-dependent pathways. (A and B) mRNA levels of TGF-β1 (A) and PAI-1 (B) in 5-HT–stimulated SSc fibroblasts (n = 9, three independent series). (C) Nuclear accumulation of p-Smad3 protein complexes after 12 and 24 h of stimulation with 1 µM 5-HT (n = 3). (D–F) mRNA expression of col 1a1 (D), col 1a2 (E), and fibronectin-1 (F) upon incubation with 500 ng/ml of neutralizing antibodies (Ab) against TGF-β1 in 5-HT–stimulated SSc fibroblasts (n = 5 each, two independent series). *, P < 0.05 compared with 5-HT–stimulated (D–F) or nonstimulated (A and B) controls. Error bars indicate SE.