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. 2011 May 9;208(5):987–999. doi: 10.1084/jem.20101773

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© 2011 Fahey et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — Persistent viral replication drives non-Tfh cells to differentiate into Tfh cells. SMARTA cells were transferred into WT mice and subsequently infected with LCMV-Cl 13. CD4⁺, CXCR5⁻ (non-Tfh) cells were isolated on day 9 after infection and transferred into WT mice that had been infected with LCMV-Cl 13 (but that had not received SMARTA cells). The contour plots depict CXCR5 expression on sorted CD4 T cells pretransfer (left) and SMARTA cells in the spleen 14 d after transfer (i.e., 23 d after infection) into LCMV-Cl 13–infected recipients. The bar graph depicts the percentage ± SD of CXCR5⁺, CD4 T cells before transfer (left) and after transfer (right). These data are representative of two individual experiments containing four mice each (*, P < 0.05).