Table I.

Patients with B cell precursor ALL and somatic mutations in IL7R

ID	IL7R mutation DNA	IL-7R mutation protein	CRLF2	JAK2	Gender	Age at Dx	WBC/liter	Events
						yr
DS46	c.819 Ins 12	243 InsPPCL	P2RY8-CRLF2	mut	M	4.9	30.5 × 109	first CCR
DS92	c.642 A>T	S185C	IGHα translocation	WT	M	15.1	112.8 × 109	first CCR
M90	c.828 Ins7 Del T	246 InsKCH	P2RY8-CRLF2	WT	M	1.7	123 × 109	relapse
M112	c.642 A>T	S185C	P2RY8-CRLF2	mut	F	14.3	9.7 × 109	relapse
M117	c.814 Ins13 Del A	241 InsFSCGP	P2RY8-CRLF2	mut	F	10.3	7 × 109	first CCR
M122	c.642 A>T	S185C	P2RY8-CRLF2	WT	M	7.0	7.3 × 109	relapse
M124	c.820 Ins10 Del C	244 InsCHL	High expression	WT	M	4.9	8.9 × 109	first CCR
M223	c.642 A>T	S185C	P2RY8-CRLF2	WT	M	8.0	27 × 109	first CCR
M61	c.820 ins21	244 InsPPVCSVT	CRLF2 not expressed	WT	M	10.7	152 × 109	relapse

DS, Down syndrome; M, male; F, female; mut, mutated at JAK2 R683; CCR, continuous complete remission; Dx, Diagnosis; Del, Deletion; Ins, Insertion; WBC, white blood cells count.