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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Behav Brain Res. 2011 Mar 4;221(1):237–245. doi: 10.1016/j.bbr.2011.02.045

Figure 4. The psychological context modulates inter-regional activity coupling.

Figure 4

Psychophysiological interaction (PPI) analysis reveals changes in regional coupling between “non-delivered shock” and “safe-no shock” conditions. Interaction effects are displayed at a threshold of T > ±2.5. Blue arrows indicate negative interactions, i.e. decreased coupling between regions in the presence of fear. Red arrows indicate positive interactions, i.e. increased coupling in the presence of fear. a) PPIs with the left red nucleus b) right hippocampus. c) Summary of PPI results with decomposed interaction effects for each seed indicating how inter-regional functional coupling changed between safe-no shock (blue boxes) and non-delivered shock (red boxes). Plots display parameter estimates with 90% confidence intervals.