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. Author manuscript; available in PMC: 2011 May 11.
Published in final edited form as: Circ Res. 2008 Mar 20;102(9):1127–1136. doi: 10.1161/CIRCRESAHA.107.163642

Figure 2. β1-RB prevents FAK tyrosine downregulation induced by MR.

Figure 2

(A) Left ventricular extracts from control, 4W-MR, and 4W-MR+β1-RB dogs were immunoprecipitated (IP) with anti-FAK antibodies and immunoblotted with anti-phosphotyrosine antibodies. Top, representative autoradiogram (with each lane from a single gel exposed for the same duration). Bottom, fold induction, n=6 each group, *P<0.05 4W-MR vs. control, #P<0.05 4W-MR+β1-RB vs. 4W-MR. (B) representative immunoblots showing accumulation of phospho-FAK Tyr-397, -576/577, -861, and -925 in LV extracts from control, 4W-MR, and 4W-MR+β1-RB. Blots were stripped and blotted with anti-FAK antibodies.