TABLE 1.
Control (n=6) |
4W-MR (n=6) |
4W-MR+β1-RB (n=6) |
|
---|---|---|---|
Heart rate, bpm | 94 ±6 | 86 ±6 | 83 ±5 |
Mean arterial pressure (mmHg) | 84 ±3 | 65 ±4* | 62 ±3* |
LV end diastolic pressure (mmHg) | 4 ±1 | 8 ±1 | 6 ±2 |
Systemic vascular resistance, dyne.s.cm−5 | 2007 ±219 | 1606 ±240 | 2342 ±176 |
Cardiac output, L/min | 3.6 ±0.4 | 3.8 ±0.6 | 2.1 ±0.1* |
LV mass, g/kg | 4.4 ±0.2 | 5.0 ±0.3 | 5.0 ±0.2 |
LV end-diastolic dimension, % change | 9.2 ±2.9† | 17.7 ±4.7† | |
LV end-systolic dimension, % change | −7.4 ±5.8 | 0.1 ±3.6 | |
LV end-diastolic wall thickness, % change | −12.0 ±8.5 | −10.2 ±5.8 | |
Wall thickness/end-diastolic dimension, % change | −18.6 ±9.3† | −20.9 ±6.5† | |
Fractional shortening, % change | 32.7 ±11.3† | 34.3 ±13.9† |
Values presented as mean±SEM.
P<0.05 vs control.
P<0.05, % change vs baseline study.