Skip to main content
. Author manuscript; available in PMC: 2011 May 11.
Published in final edited form as: Nat Genet. 2010 Sep 5;42(10):859–863. doi: 10.1038/ng.658

Figure 3.

Figure 3

PRDM9 variation influences crossover activity at hot-spots MSTM1a and MSTM1b. (a) Variant alleles present in men previously typed for sperm crossovers at these hot spots16; all other men were A/A homozygotes. RFs at each hot spot are shown, together with 95% CIs. Note that alleles L9/L24 associate not only with MSTM1a activity but also apparently with elevated RF at MSTM1b (P = 0.035). (b) DNA sequence structures of these alleles, coloured as in Fig. 2, plus amino acid sequence changes relative to allele A, with locations given with respect to the main ZnF DNA-contact residues (−1, 2, 3 and 6)15.