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. Author manuscript; available in PMC: 2011 May 11.
Published in final edited form as: Nat Genet. 2006 Aug 6;38(9):1071–1076. doi: 10.1038/ng1860

Figure 5.

Figure 5

HP1 counteracts tumorigenesis induced by JAK/STAT overactivation. (a) A moderate increase in HP1 levels by the basal expression from an hsp70-Su(var)205 transgene completely suppresses hopTum-l-dependent hematopoietic tumors. Shown are representative flies of indicated genotypes and the tumor index calculated from 500 flies. (b) The enlarged eye phenotype, due to eye cell overproliferation induced GMR-upd (second from left), is enhanced by halving the dosage of HP1 (second from right) and suppressed by the basal expression of hsp70-Su(var)205 (far right). Double arrows indicate the widths of eyes of females of indicated genotypes viewed dorsally. Single arrows point to the furrow due to eye enlargement induced by GMR-upd, which is deepened when HP1 levels are reduced (second from right) and nearly absent when HP1 levels are increased (right). (c) Eye size was quantified by measuring the pixel numbers of more than five representative eye pictures (taken dorsally at the same magnification and distance) of indicated genotypes. * P < 0.01 (Student's t-test).