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. 2011 Apr 24;1:263–273. doi: 10.7150/thno/v01p0263

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Mean ΔR₂* curves of tumor ROI from cRGD- (black symbols) and cRAD-SPPM (gray symbols) in mice bearing A549 (A), MDA-MB-231 (B) or U87 (C) subcutaneous xenografts (n=3 for each xenograft group). Squares, circles and triangles indicate the mean of three measured ROIs from one animal in each group. cRGD-SPPM tumor hot-spot ROIs (black symbols) show a continuous increase in the ΔR₂* over 30 mins, indicating SPPM accumulation in tumor tissues. In comparison, the ΔR₂* values from cRAD-SPPM treated animals (gray symbols) show a maintained or trend toward baseline indicating clearance from the tumor tissue.