Table 1.
Semi-Quantitative Analysis of Biocompatibility and Bone Formation After 8 Weeks Implantation Applying a Score System in Three Different Zones from the Border Towards Centre of the Former Defect
| Variable | Group | Zone 1 | Zone 2 | Zone 3 | Total |
|---|---|---|---|---|---|
| Lymphocytes/plasma cells a | PLGA/CaP PLGA/Ag-CaP |
0.3 ± 0.5 0.3 ± 0.5 |
0.3 ± 0.5 0.1 ± 0.4 |
0.1 ± 0.4 0.0 ± 0.0 |
0.7 ± 0.5 0.4 ± 0.7 |
| Macrophages a | PLGA/CaP PLGA/Ag-CaP |
1.0 ± 0.0 1.1 ± 0.4 |
1.1 ± 0.4 0.9 ± 0.4 |
1.1 ± 0.4 0.9 ± 0.4 |
3.3 ± 0.8 2.9 ± 0.8 |
| Fibroblasts/fibrocytes a | PLGA/CaP PLGA/Ag-CaP |
0.0 ± 0.0 0.0 ± 0.0 |
0.1 ± 0.4 0.0 ± 0.0 |
0.0 ± 0.0 0.0 ± 0.0 |
0.1 ± 0.4 0.0 ± 0.0 |
| Foreign body giant cells b | PLGA/CaP PLGA/Ag-CaP |
0.0 ± 0.0 0.3 ± 0.5 |
0.3 ± 0.5 0.5 ± 0.5 |
0.3 ± 0.5 0.3 ± 0.5 |
0.6 ± 0.8 1.0 ± 0.9 |
| Macrophages circles b | PLGA/CaP PLGA/Ag-CaP |
0.3 ± 0.5 0.6 ± 0.7 |
0.9 ± 0.4 0.8 ± 0.7 |
0.7 ± 0.5 0.8 ± 0.5 |
1.9 ± 0.9 2.1 ± 1.5 |
| Bone islands b | PLGA/CaP PLGA/Ag-CaP |
0.3 ± 0.5 0.6 ± 0.5 |
0.9 ± 0.4 0.8 ± 0.4 |
0.4 ± 0.5 0.3 ±0 .5 |
1.6 ± 0.8 1.6 ± 0.9 |
| Osteoclasts b | PLGA/CaP PLGA/Ag-CaP |
0.4 ± 0.5 0.8 ± 0.5 |
0.1 ± 0.4 0.3 ± 0.5 |
0.1 ± 0.4 0.0 ± 0.0 |
0.7 ± 1.0 1.0 ± 0.8 |
a
Scores (0 for 0%, 1 for 1-25%, 2 for 26-50%, 3 for > 50%) for percentage fraction of the cells per power field and the corresponding sum for each cell type.
b
Scores (0 for none, 1 for 1-5, 2 for 6-10, 3 for > 11) for the absolute number of the cells per power field and the corresponding sum for each cell type.