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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Nat Protoc. 2011 Apr 21;6(5):656–667. doi: 10.1038/nprot.2011.317

Figure 4. Regeneration of benign and transformed human prostate glands in vivo.

Figure 4

(a) Basal cells without genetic manipulation generate phenotypically benign glands with expression of prostate-specific antigen (PSA) indicating differentiation to the luminal lineage. Scale bars, 100 μm. (b) Basal cells manipulated to express selected oncogenes can generate malignant lesions, characterized by increased staining for PSA and loss of basal cells. Scale bars, 100 μm. (c) High-power images of benign tissue stained for the transcription factors p63 and AR reveal the presence of distinct layers of p63+ AR-low basal cells and p63- AR+ luminal cells. Scale bars, 25 μm.

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