Figure 6.

The C₂B hydrophobic mutation inhibits evoked transmitter release more severely than the syt^null mutation. A, Representative current traces recorded from embryonic muscle fiber 6. B, The mean EJC amplitude in transgenic control embryos was 1782 ± 224 pA (−/−; P[syt^WT], n = 8), in P[syt^B-IE] mutant embryos was 312.2 ± 62.6 pA (−/−; P[syt^B-IE], n = 8), and in syt^null mutants was 625.2 ± 89.0 pA (−/−, n = 11). Evoked release in P[syt^B-IE] was significantly less than in syt^null mutants (* vs **, p < 0.02).