Table 1.
Characteristics of trypanosomatids' phosphotransferases. Summary of the main features of arginine kinases (AKs), adenylate kinases (ADKs), and nucleoside diphosphate kinases (NDPKs) isoforms from trypanosomatids. Predicted subcellular localizations are indicated with a question mark. The existence or not of human equivalents (human), N- or C-terminal extensions (N-t and C-t), peroxisomal targeting signal (PTS-1), and DM10 motifs are also detailed.
| Enzyme | Organism | Isoform | Localization | Human | Features |
|---|---|---|---|---|---|
| AK | T. cruzi/T.brucei | 1 | Cytosol | No | Canonical |
| T. brucei | 2 | ? | No | N-t | |
| 3 | ? | No | C-t | ||
| ADK | T. cruzi/T. brucei/L. major | 1 | Flagellum | Yes | N-t |
| 2 | Reservosome (?) | Yes | — | ||
| 3 | Glycosome | Yes | PTS-1 | ||
| 4 | Flagellum | Yes | N-t | ||
| 5 | Cytosol | Yes | Canonical | ||
| 6 | Mitochondria | Yes | — | ||
| T. brucei | 7 (A) | Flagellum | Yes | N-t | |
| NDPK | T. cruzi/T. brucei/L. major | 1 | Nucleus (?) | Yes | Canonical |
| 2 | Cytoskeleton | Yes | DM10 | ||
| 3 | ? | Yes | DM10 | ||
| T. cruzi/T. brucei | 4 | ? | Yes | Putative | |