Table 2.
Summary of association studies of the UCP2 promoter −866G>A (rs659366) polymorphism in relation to obesity and related metabolic traits.
| Ethnic population | nobese (Frequency of A-allele in %) | ncontrol (Frequency of A-allele in %) | Phenotypes | Reference |
|---|---|---|---|---|
| Caucasian | 340 (46.5) | 256 (52.2) | Common G-allele predisposed to obesity | Esterbauer et al. 2001 [74] |
| 109 (31.2) | 589 (38.2) | |||
| Caucasian | 749 (39.6) | 816 (40.7) | Not associated with obesity or BMI within groups | Dalgaard et al. 2003 [60] |
| Caucasian | 122 (28.2) | 374 (29.0) | Not associated with obesity or BMI within groups | Mancini et al. 2003 [79] |
| 76 (34.9) | ||||
| Caucasian | — | 302 (32.1) | Not associated with BMI within group | Sesti et al. 2003 [72] |
| Caucasian | — | 565 (32.4) | Not associated with BMI in control or diabetic patients | D'Adamo et al. 2004 [80] |
| — | 483 (33.6) | |||
| Japanese | — | 134 | Not associated with BMI, but with hypertension | Ji et al. 2004 [81] |
| 342 | ||||
| Caucasian | 296 (37.0) | — | A-allele associated with decreased lipid oxidation | Le Fur et al. 2004 [89] |
| Caucasian | — | 327 (34.6) | Not associated with BMI within group | Bulotta et al. 2005 [82] |
| 746 (28.6) | ||||
| Pima | 864 (54.0) | — | Not associated with BMI within group. AA genotype increased 24 hr EE | Kovacs et al. 2005 [83] |
| Indians | 263 (55.5) | — | ||
| Korean | — | 658 | Not associated with BMI within group. Associated with decreased HDL-levels | Cha et al. 2007 [59] |
| Caucasian | — | 598 | Not associated with BMI within group. A-allele associated with decreased W/H-ratio and lower fasting p-insulin | Gable et al. 2007 [84] P |
| 653 | ||||
| Filipino | — | 1755 (29.7) | Not associated with BMI within group | Marvelle et al. 2008 [85] |
| Caucasian | 375 (41.3) | 2316 (35.8) | A-allele associated with obesity and associated with increased risk of CHD and systolic BP. AA genotype associated with increased oxidative stress | Dhamrait et al. 2004 [77] |
| Caucasian | 192 (38.3) | 170 (38.2) | AA genotype significantly associated with obesity and insulin resistance in children | Ochoa et al. 2007 [76] |
| Caucasian | 225 (39.6) | 294 (38.9) | AA genotype associated with various indices of obesity | Kring et al. 2008 [78] |
| Caucasian | 277 | 188 | Not associated with early-onset obesity | Schäuble et al. 2003 [86] |
| Caucasian | — | 681 (36.9) | Not associated with BMI in type 2 diabetic patients, but AA genotype associated with increased triglyceride and cholesterol levels | Reis et al. 2004 [90] |
| Various | — | 3784 (35.4–46.7) | Not associated with obesity, allele-frequencies not given for obese subjects | Hsu et al. 2008 [87] |
| Korean | — | 1469 (~48) | GG genotype associated with obesity in children but protective in adults | Jun et al. 2009 [75] |
| Caucasian | — | 507 | AA genotype decreased total cholesterol and decreased LDL-cholesterol. Not associated with BMI within group | Salopuro et al. 2009 [88] P |
| Indian | 200 (42.0) | 240 (32.2) | A-allele associated with obesity and hyperinsulinemia (in obese subjects) | Srivastava et al. 2010 [91] |
PDenotes prospective study. Abbreviations: CHD: coronary heart disease; BP: blood pressure; EE: energy expenditure; BMI: body mass index; HDL: high density lipoprotein; W/H: waist to hip.