Table 2.
Summary of studies showing associations between β2-adrenoceptor polymorphisms and obesity.
| Authors [reference] | Year | Population | Subjects | Findings |
|---|---|---|---|---|
| Large et al. [55] | 1997 | Swedish | Caucasian women with wide range of obesity | Gln27Glu polymorphism was associated with obesity. |
| Echwald et al. [58] | 1998 | Danes | Caucasian juvenile-onset obese men | No association between Gln27Glu and obesity. |
| Hellström et al. [59] | 1999 | Swedish | Swedish-Caucasian men and women | Gln27Glu polymorphism was associated with obesity only in women, but not in men. |
| Kortner et al. [69] | 1999 | German | Caucasian with morbid obesity | Gln27Glu polymorphism was not associated with obesity. |
| The Quebec Family Study [70] | 2000 | Canadian | Caucasian men and women | Gln27Glu polymorphism was associated with obesity and hyperlipidemia. |
| Ukkola et al. [56] | 2001 | USA | 12 pairs of twins, Caucasians | Gln27Glu polymorphism was associated with weight gain (obesity). |
| Meirhaeghe et al. [71] | 2000 | French | 1,195 subjects | Subjects carrying Gln27 homozygous had an increased risk of obesity in men, but not in women. Further, men with Gln27 homozygous carried in addition the Arg16 allele, had more significant increase in body weight, BMI and waist-to-hip ratio (central obesity). |
| The HERITAGE family study [72] | 2003 | Canada | Sedentary black and white men | Gln27Glu polymorphism was associated with lower fat in obese white men. |
| Pereira et al. [25] | 2003 | Brazilian | 1,576 individuals randomly selected | Subjects carrying Gln27 homozygous had higher risk of obesity, whereas those with Gly27 homozygous had increased risk of hypertension. |
| Jiao et al. [73] | 2005 | Scandinavian | 1,354 women and 421 men | Common haplotypes of ADRB2 polymorphisms had recessive effects against excess body fat only in women, but not in men. |
| Masuo et al. [26] | 2005 | Japanese | 154 overweight/obese men | Gly16 allele was related to obesity and rebound weight gain in weight-loss study. |
| Masuo et al. [24, 27] | 2005 | Japanese | 160 nonobese, normotensive men | Gly16 allele was related to future weight gain, BP elevation and insulin resistance in originally nonobese, normotensive men. |
| Masuo et al. [28] | 2006 | Japanese | 329 normotensive men with a wide range of BMI | Gly16 and Glu27 alleles were related to obesity through blunted-leptin-mediated sympathetic activity. |
| Kawaguchi et al. [29] | 2006 | Japanese | 55 overweight/obese men | Gly16 allele was related to further weight gain in obese subjects. |
| Petrone et al. [74] | 2006 | European | 642 overweight/obese subjects | The haplotype of 5′LC-Cys(19)Arg(16)Gln(27) was related to additional weight gain with increases of triglycerides and LDL-cholesterol. |
| Gjesing et al. [75] | 2009 | Danes | 6,514 adults | No consistent effect of ADRB2 haplotypes on obesity and quantitative traits of body fatness. |
ADRB2: β2-adrenoceptors; BP: blood pressure.