Table 4.
Correlation between DNA hypermethylation and mRNA expression of DNMT3b in ESCC (n = 46)
| DNMT3b mRNA expression (%) | p value | ||
| Upregulated | Not upregulated | ||
| p16 | |||
| methylated | 90.0 | 10.0 | 0.022 |
| unmethylated | 57.7 | 42.3 | |
| p14 | |||
| methylated | 57.1 | 42.9 | 0.385 |
| unmethylated | 74.4 | 25.6 | |
| DAPK | |||
| methylated | 77.3 | 22.7 | 0.521 |
| unmethylated | 66.7 | 33.3 | |
| RAR-β | |||
| methylated | 66.7 | 33.3 | 0.527 |
| unmethylated | 76.0 | 24.0 | |
| CDH1 | |||
| methylated | 73.7 | 26.3 | 1 |
| unmethylated | 70.4 | 29.6 | |
| APC | |||
| methylated | 83.3 | 16.7 | 0.659 |
| unmethylated | 70.0 | 30.0 | |
| TIMP3 | |||
| methylated | 83.3 | 16.7 | 0.659 |
| unmethylated | 70.0 | 30.0 | |
| MGMT | |||
| methylated | 66.7 | 33.3 | 1 |
| unmethylated | 72.5 | 27.5 | |
| RASSF1A | |||
| methylated | 66.7 | 33.3 | 1 |
| unmethylated | 72.5 | 27.5 | |
| FHIT | |||
| methylated | 50.0 | 50.0 | 0.49 |
| unmethylated | 72.7 | 27.3 | |
| More genes methylation | |||
| ≥2 genes | 82.4 | 17.6 | 0.021 |
| <2 genes | 41.7 | 58.3 | |