Table 5.

Diagnostic information of serum DNA methylation at five genes

Gene	AUC (95%, CI)	Sensitivity (%)	Specificity (%)
p16	0.533 (0.369–0.698)	6.7	100
DAPK	0.800 (0.673–0.927)	73.3	86.7
RAR-β	0.567 (0.405–0.728)	26.7	86.7
CDH1	0.822 (0.689–0.955)	84.4	80.0
RASSF1A	0.778 (0.655–0.901)	62.2	93.3
Any gene	0.733 (0.561–0.906)	100.0	46.7
Two or more genes	0.911 (0.839–0.983)	82.2	100.0

CI, confidence interval.