Table 1.
Predicted cleavage site for MMP-2 (Turk et al., 2001) mediated DMP1 cleavage (P for position in the cleavage-site motif, knowing that the cleavage occurs between P1 and P1′ residues). The number of occurrences of each residue that arise more than once is given for each position. In the protein sequence, the signal peptide appears in italics and the P1 and P1′ positions are underlined. These sites are also present within the mouse sequence (NP_058059).
| P5 | P4 | P3 | P2 | P1 | P1′ | P2′ | P3′ | |
|---|---|---|---|---|---|---|---|---|
| Rat DMP1 sequence (NP_987089) | ||||||||
| E59-L60GS | 1.3 | 4.2 | 2.2 | |||||
| AG78-M79DA | 1.3 | 1.4 | 2.8 | 2.2 | ||||
| E170-Y171R | 1.3 | 1.9 | 1.5 | |||||
| E188-F189 | 1.3 | 1.8 | ||||||
| G193-M194QS | 1.4 | 2.8 | 2.2 | |||||
| E240-F241 | 1.3 | 1.8 | ||||||
| DDRGE260-L261 | 1.4 | 1.3 | 4.2 | |||||
| S380-L381 | 1.9 | 4.2 | ||||||
| NESLS382-L383 | 1.3 | 1.9 | 4.2 | |||||
| G401-L402QS | 1.4 | 4.2 | 2.2 |
NP_987089.1 dentin matrix protein 1 [Rattus norvegicus]
MKTVILLTFLWGLSCALPVARYQNTESESSEERTGNLAQSPPPPMANSDHTDSSESGEELGSDRSQYRP AGGLSKSAGMDADKEEDEDDSGDDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQ ENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPG STRSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSR ETQSVSTEDFRSKEESRSETQEDTAETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGD NPDNTSQTGDQRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESAQDEDSSSQEGLQS QSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSSSEEDNHPKNIEADNRKLIVDAY HNKPIGDQDDNDCQDGY