Table 2.
Association between Two-year Changes from Baseline in Osteocalcin and Concurrent Alveolar Bone Density (computer-assisted densitometric image analysis [CADIA]), Alveolar Bone Height, Lumbar Spine Bone Mineral Density (BMD), and Femoral Neck Bone Mineral Density (BMD) Changes (n = 113)
| Bone Measure | Biomarker Change Category | Difference in MeanBone Changes | 95% CI** | p-value |
|---|---|---|---|---|
| CADIA changes(CADIA units) | Lowest tertile (< −6.5 ng/mL) | 0 (reference) | ||
| Intermediate tertile (−6.5 to −0.5 ng/mL) | −1.38 | −2.95 to 0.19 | 0.086 | |
| Highest tertile (> −0.5 ng/mL) | −3.56 | −5.10 to −2.03 | < 0.0001 | |
| Alveolar bone height changes (mm)* | Lowest tertile (< -6.5 ng/mL) | 0 (reference) | ||
| Intermediate tertile (−6.5 to −0.5 ng/mL) | 0.019 | −0.022 to 0.059 | 0.37 | |
| Highest tertile (> −0.5 ng/mL) | 0.016 | −0.027 to 0.059 | 0.47 | |
| Lumbar spine BMD% changes | Lowest tertile (< −6.5 ng/mL) | 0 (reference) | ||
| Intermediate tertile (−6.5 to −0.5 ng/mL) | −0.35% | −2.07% to 1.38% | 0.69 | |
| Highest tertile (> −0.5 ng/mL) | −3.13% | −4.80% to −1.46% | 0.0002 | |
| Femoral neck BMD% changes | Lowest tertile (< −6.5 ng/mL) | 0 (reference) | ||
| Intermediate tertile (−6.5 to −0.5 ng/mL) | −1.78% | −3.84% to 0.28% | 0.091 | |
| Highest tertile (> −0.5 ng/mL) | −2.82% | −4.65% to −0.99% | 0.0025 |
*
Alveolar bone height change was calculated as two-year alveolar bone height (mm) minus baseline alveolar bone height (mm). A positive difference reflects alveolar bone height loss.
**
CI, confidence interval.