Fig. 10.

An in vitro model for the 5-HT-modulated suppression of AS amyloidogenesis. In a first step, amyloid-promoting conformational rearrangements of AS occur (A). During the consequent build-up of intermediate aggregates (B), the C-terminal region of AS (dashed line) remains solvent exposed [55,56]. 5-HT molecules (gray spheres) bind to the C-terminal region (C) and arrest the build-up of mature amyloid fibrils (F). Instead, intermediate, partially structured, toxic aggregates become stabilized (D). Their conversion into amyloid fibrils is kinetically disfavored (E).