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Immunologic effects of vitamin D that may influence autoimmune diseases
| Cell type | Vitamin D effect |
|---|---|
| Dendritic cells | ↓CD40, CD80, CD86, IL-12 expression |
| ↑IL-10 expression | |
| ↑Chemokines that attract Tregs | |
| T cells | ↓Th1 and Th17 action (possible) |
| ↑Tregs | |
| B cells | ↓Proliferation and differentiation |
| ↑Apoptosis |
IL—interleukin; Th1—T-helper type 1; Th17—T-helper type 17; Treg—regulatory T cell
