Table 1.
Baseline characteristics of the total study population and of each subgroup by previous treatment*
| Previous treatment subgroup | ||||
|---|---|---|---|---|
| Characteristic | Treatment- naïve | AR pretreated | Inadequate AR responder | Total |
| N (%) | 181 (23.9) | 209 (27.6) | 368 (48.5) | 758 (100.0) |
| Age (years) | 70.4 (7.7) | 69.3 (7.2) | 69.8 (7.5) | 69.8 (7.5) |
| Time since menopause (years) | 22.7 (9.5) | 21.4 (9.0) d | 23.4 (9.9) | 22.7 (9.6) |
| Weight (kg) | 64.4 (11.6)a | 62.8 (10.9) | 61.3 (10.9) | 62.5 (11.1) |
| Height (cm) | 158.3 (7.0) a | 157.8 (7.1) a | 155.7 (7.4) | 156.9 (7.3) |
| BMI (kg/m2) | 25.7 (4.4) | 25.3 (4.4) | 25.2 (4.0) | 25.4 (4.2) |
| Lumbar spine BMD (g/cm2) | 0.751 (0.114) b | 0.746 (0.120) | 0.728 (0.117) | 0.738 (0.118) |
| Lumbar spine BMD (T-Score) | −3.01 (0.96) c | −3.16 (0.91) d | −3.35 (0.95) | −3.21 (0.95) |
| Total hip BMD (g/cm2) | 0.703 (0.105) | 0.703 (0.111) | 0.687 (0.110) | 0.695 (0.110) |
| Femoral neck BMD (g/cm2) | 0.622 (0.108) | 0.632 (0.116) | 0.620 (0.116) | 0.624 (0.114) |
*for definition of patient subgroups, see the “Participants” sub-heading in the Methods section.
Data are presented as mean (standard deviation) with ANOVA test. Only patients with non missing biochemical markers at baseline are included
BMI = body mass index
BMD = bone mineral density
ap < 0.005 vs Inadequate responders; bp < 0.05 vs Inadequate responders; cp = 0.0001 vs Inadequate responders; dp < 0.05 vs Inadequate responders