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. 2011 Jun 1;56(3):1814–1821. doi: 10.1016/j.neuroimage.2011.03.002

Fig. 2.

Fig. 2

Statistical parametric maps (SPMs) of grey matter loss associated with impaired emotion recognition from music and faces in FTLD. Maps are based on separate-modality regression analyses (see Methods). SPMs are presented on sections of the mean normalised T1-weighted structural brain image in MNI stereotactic space; the left hemisphere is on the left and slice coordinates in mm are shown. For music, SPMs are thresholded at p < 0.05 FDR corrected for multiple comparisons over the whole brain volume; for faces, SPMs are thresholded at p < 0.001 uncorrected for display purposes. The SPMs for music and face emotion recognition show common regional grey matter associations in anterior insula (b,h) and lateral orbitofrontal cortex (a,g). In addition, the SPM for music emotion recognition shows grey matter associations in anterior cingulate (b,c), medial prefrontal cortex (a,c), anterior and superior temporal cortices (d,e,f), fusiform and parahippocampal gyri (e,f), more posterior parietal cortices (e), limbic areas including amygdala and hippocampus (d,e), and other subcortical structures including nucleus accumbens (c,d) and ventral tegmentum (e).