Table 1.
Anti-inflammatory activity of the ethanolic extract of Psidium guajava leaves on carrageenaninduced rat paw edema in albino rats
| Group | Drug dose p.o. | Mean increase in paw volume (Mean ± SEM) (mL)(% Inhibition within parentheses) |
|||
|---|---|---|---|---|---|
| 1st h | 2nd h | 3rd h | 4th h | ||
| A (Control) | 10 mL/kg | 0.20 ± 0.02 | 0.28 ± 0.01 | 0.54 ± 0.04 | 0.30 ± 0.05 |
| B (PGE) | 250 mg/kg | 0.15 ± 0.04a,b | 0.20 ± 0.01a,b | 0.34 ± 0.08a,b | 0.19 ± 0.07a,b |
| (25.00%) | (28.57%) | (38.46%) | (36.66%) | ||
| C (PGE) | 500 mg/kg | 0.11 ± 0.01a,b | 0.13 ± 0.06a,b | 0.23 ± 0.04a,c | 0.13 ± 0.01a,c |
| (45.00%) | (53.57%) | (58.82%) | (56.66%) | ||
| D (Aspirin) | 100 mg/kg | 0.09 ± 0.01a | 0.11 ± 0.07a | 0.20 ± 0.02a | 0.11 ± 0.01a |
| (55.21%) | (60.71%) | (64.70%) | (62.12%) | ||
| F | 285 | 400.4 | 175.9 | 355.9 | |
| One-way ANOVA | df | 20,3 | 20,3 | 20,3 | 20,3 |
| P | <0.05 | <0.05 | <0.05 | <0.05 | |
PGE, Psidium guajava; SEM, standard error of mean; ANOVA, analysis of variance, Values = Mean±SEM, n = 6 in each group;
a → P < 0.05 when compared with control;
b → P < 0.05 when compared with standard;
c → P > 0.05 when compared with standard; ANOVA followed by Dunnet’s multiple comparison test.