Table 3.
Anti-inflammatory activity of the ethanolic extract of Psidium guajava leaves on carrageenaninduced rat paw edema in albino rats
| Group | Drug dose p.o. | Increase in paw volume in mL (% inhibition in parentheses) |
Weight change on 21st day (% change in parentheses) | Arthritis index | |
|---|---|---|---|---|---|
| On 5th day | On 21st day | ||||
| A (Control) | 10 mL/kg | 0.92 ±0.02 | 0.52 ± 0.01 | -28 0.32 | 7.8 0.24 |
| B (PGE) | 250 mg/kg | 0.74±0.03A,B | 0.20±0.02a,b | -15 ± 0.21a,b | 5.9 ± 0.16A,B |
| (20.12%) | (62.14%) | (46.42%) | |||
| C (PGE) | 500 mg/kg | 0.67±0.12a,b | 0.140.04a,c | -10 0.3a,b | 4.5 0.14a,b |
| (28.04%) | (74.18%) | (64.28%) | |||
| D (Aspirin) | 100 mg/kg | 0.56 0.02a | 0.11±0.02a | -5 0.14a | 3.2 0.10a |
| (39.18%) | (80.67%) | (82.14%) | |||
| One-way | F | 182.8 | 82.36 | 66.80 | 96.32 |
| ANOVA | df | 20,3 | 20,3 | 20,3 | 20,3 |
| P | <0.05 | <0.05 | <0.05 | <0.05 | |
PGE, Psidium guajava; SEM, standard error of mean; ANOVA, analysis of variance, Values = Mean±SEM, n = 6;
a → P < 0.05 when compared with control;
b → P < 0.05 and
c → P > 0.05 when compared with standard; ANOVA followed by Dunnet’s multiple comparison test in albino rats.