Figure 2.
Individual Cmax (A) and AUC (B) values of aliskiren in 12 healthy volunteers during orange juice, apple juice and water phases. The numbers refer to the participant numbers in Table 2. The volunteers ingested 200 ml of orange juice, apple juice or water three times a day for 5 days, and a single 150-mg dose of aliskiren on day 3, together with the first orange juice, apple juice or water dose of the day. AUC, area under the plasma concentration–time curve; Cmax, peak plasma concentration