Figure 3.

Change in aliskiren AUC by orange juice (○) and apple juice (▵) plotted against aliskiren AUC during the water phase. The volunteers ingested 200 ml of orange juice, apple juice or water three times a day for 5 days, and a single 150-mg dose of aliskiren on day 3, together with the first orange juice, apple juice or water dose of the day. AUC, area under the plasma concentration–time curve