Table 1.
Drugs implicated as perpetrators of CYP-mediated PK-DDIs that are not available in Australia or New Zealand
| CYP1A2 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A |
|---|---|---|---|---|
| Armodafinil | Azapropazone | Armodafinil | Clemastine | Armodafinil |
| Artemisinin | Benzbromarone | Artemisinin | Deramciclan | Chloramphenicol* |
| Clinafloxacin | Bucolome | Halofantrine | Clotrimazole* | |
| Enoxacin | Indisulam | Hydroxyzine | Conivaptan | |
| Etintidine | Lornoxicam | Levomepromazine | Diethyldithiocarbamate | |
| Furafylline | Miconazole* | Melperone | Mibefradil | |
| Idrocilamide | Nizatidine | Mepyramine | Miconazole* | |
| Mibefradil | Oxandrolone | Mibefradil | Nefazodone | |
| Nafcillin | Phenylbutazone | Midodrine | Nelfinavir | |
| Perfloxacin | Secobarbital | Perphenazine | Quinidine | |
| Phenylpropanolamine | Stiripentol | Propafenone | Stiripentol | |
| Pipemidic acid | Sulfamethizole | Quinidine | Sulfadimidine | |
| Rofecoxib | Sulfaphenazole | Ranolazine | Sulfinpyrazone | |
| Stiripentol | Sulfinpyrazone | Rofecoxib | Telithromycin | |
| Thiabendazole | Stiripentol | Tofisopam | ||
| Troleandomycin | Thioridazine | Troglitazone | ||
| Zileuton | Tripelennamine | Troleandomycin |
*
Systemic preparations not available. PK-DDI, pharmacokinetic drug–drug interactions.