Table 1.
Cases of reversible posterior leucoencephalopathy syndrome after sunitinib therapy
| Case # | Age (years)/Gender | Indication for sunitinib therapy | Onset after starting sunitinib | Clinical presentation | Blood pressure (mmHg) at presentation | Management | Recovery after sunitinib discontinuation |
|---|---|---|---|---|---|---|---|
| Case 1 [3] | 54/F | Imatinib-resistant gastrointestinal stromal cell tumour | 8 months | Vision loss, generalized seizures, thromocytopenia | 210/110 (previously had suboptimally controlled hypertension) | Sunitinib discontinuation, anticonvulsants, antihypertensives, fresh frozen plasma | Complete recovery in 10 days |
| Case 2 [4] | 70/F | RCC, bone metastases | 2 weeks | Headache, vision loss, partial seizures | 170/100 (previous condition not specified) | Sunitinib discontinuation, anticonvulsants, antihypertensives | Complete recovery in few days |
| Case 3 [5] | 81/F | RCC, liver and lung metastases | 5 months | Diziness, unconsciousness, Confusion | 130/74 (had well controlled hypertension) | Sunitinib discontinuation | Complete recovery in 1 month |
| Case 4 [6] | 39/F | RCC, ovarian metastases | 1 week | Headache, confusion, generalized seizures, hemiplegia, visual disturbances | 160/102 (previously normotensive) | Sunitinib discontinuation, anticonvulsants, antihypertensives | Complete recovery in 2 weeks |
| Case 5 [7] | 48/F | RCC, retroperitoneal lymph node metastases | 1 week | Headache, generalized seizures, unsteadiness | 190/130 (previously had well controlled hypertension) | Sunitinib discontinuation | Complete recovery in 3 weeks |
| Present case | 65/M | RCC, vertebral metastases | 8 days | Headache, weakness in upper limbs, generalized seizures, visual loss | 160/100 (previously normotensive) | Sunitinib discontinuation, antihypertensive | Complete recovery in 17 days |