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. Author manuscript; available in PMC: 2011 Sep 2.
Published in final edited form as: Oncogene. 2010 Jun 21;29(35):4896–4904. doi: 10.1038/onc.2010.234

Figure 4. LSD1 is recruited to epithelial gene promoters by Snai1.

Figure 4

(A) Occupancy of LSD1 at the E-cadherin promoter is increased in Snai1-expressing cells compared to control MCF10A cells as shown by ChIP analysis with the LSD1 antibody.

(B) The binding of LSD1 to the CLDN7 and KRT8 promoters is increased in MCF10A cells expressing Snai1.

(C) Quantitative RT-PCR analysis shows efficient depletion of Snai1 in MDA-MB-231 cells by a retroviral shRNA.

(D) The presence of LSD1 at the E-cadherin and CLDN7 promoters is reduced in MDA-MB-231 cells depleted of Snai1.