Table 4. Proportion of patients improving, having no change, or worsening from baseline to Week 16 for each cognitive test.

Cognitive Test Outcome	N. (%) of patients
	Lamotrigine (n=15)	Topiramate ()*
COWA Test
Improved	11 (73)	2 (13)
No change	2 (13)	0 (0)
Worsened	1 (8)	12 (92)
Stroop Color-Word Interference Test
Improved	10 (67)	8 (62)
No change	0 (0)	0 (0)
Worsened	5 (33)	5 (38)
Digit Cancellation Test, total minus errors
Improved	7 (47)	12 (100)
No change	0 (0)	0 (0)
Worsened	8 (53)	0 (0)
LGP Test, dominant hand
Improved	7 (47)	9 (69)
No change	1 (7)	0 (0)
Worsened	7 (47)	4 (31)
RAVLT, delayed recall
Improved	9 (60)	10 (77)
No change	2 (13)	1 (8)
Worsened	4 (27)	2 (15)
Symbol-Digit Modalities Test (correct number)
Improved	9 (60)	2 (17)
No change	0 (0)	0 (0)
Worsened	6 (40)	10 (83)

COWA, Controlled Oral Word Association; LGP, Lafayette Grooved Pegboard; RAVLT, Rey Auditory-Verbal Learning Test.

^*n=12 for the Digit Cancellation Test and Symbol-Digit Modalities Test.