Table 3.

Incidence of Neoatherosclerosis Stratified by the Duration of Implant

	BMS (197 lesions)	DES			P value BMS vs. DES (SES + PES)
		All (SES + PES) (209 lesions)	SES (103 lesions)	PES (106 lesions)
Duration with any neoatherosclerosis, days	2160 (1800, 2880)	420 (361, 683)	450 (361, 660)	383 (270, 721)	<0.001
Incidence of any neoatherosclerosis
≤ 2 years	0/88 (0)	51/177 (29)	32/87 (37)	19/90 (21)*	<0.001
> 2 years, ≤ 6 years	17/76 (22)	13/32 (41)	7/16 (44)	6/16 (38)	0.053
> 6 years	14/33 (42)	-	-	-	-
All	31/197 (16)	64/209 (31)	39/103 (38)	25/106 (24)†	<0.001
Incidence of foamy macrophage clusters
≤ 2 years	0/88 (0)	25/177 (14)	10/87 (12)	15/90 (17)	<0.001
> 2 years, ≤ 6 years	2/76 (3)	6/32 (19)	4/16 (25)	2/16 (13)	0.004
> 6 years	3/33 (9)	-	-	-	-
All	5/197 (3)	31/209 (15)	14/103 (14)	17/106 (16)	<0.001
Incidence of fibroatheromas
≤ 2 years	0/88 (0)	23/177 (13)	19/87 (22)	4/90 (4)‡	<0.001
> 2 years, ≤ 6 years	11/76 (15)	7/32 (22)	3/16 (19)	4/16 (25)	0.346
> 6 years	8/33 (24)	-	-	-	-
All	19/197 (10)	30/209 (14)	22/103 (21)	8/106 (8)§	0.145
Incidence of TCFA/plaque rupture
≤ 2 years	0/88 (0)	3/177 (2)	3/87 (4)	0/90 (0)	0.219
> 2 years, ≤ 6 years	4/76 (5)	0/32 (0)	0/16 (0)	0/16 (0)	0.186
> 6 years	3/33 (9)	-	-	-	-
All	7/197 (4)	3/209 (1)	3/103 (3)	0/106 (0)	0.169
Calcified neointima	9 (5)	11 (5)	7 (7)	4 (4)	0.747
Location of neoatherosclerosis
Proximal lesion	21/77 (27)||	34/102 (33)||	19/45 (42)	15/57 (26)	0.384
Mid/Distal lesion	10/84 (12)	30/100 (30)	20/53 (37)	10/47 (21)	0.003

Values are expressed as medians (interquartile range) or n (%).

^*p=0.021 vs. SES group,

^†p=0.025 vs. SES group,

^‡p<0.001 vs. SES group, and

^§p=0.004 vs. SES group.

^||Incidence of atherosclerotic change in proximal lesion was higher than those in mid/distal lesion in BMS group (27% vs. 12%, p=0.014), but not in DES group (33% vs. 30%, p=0.611).

BMS = bare metal stents, DES = drug-eluting stents, PES = paclitaxel-eluting stents, SES = sirolimus-eluting stents, TCFA = thin-cap fibroatheroma