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. 2011 May 15;22(10):1664–1676. doi: 10.1091/mbc.E10-09-0745

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© 2011 Majumdar et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 8: — Model for lysosomal pH regulation in microglia. Model for the regulation of lysosomal pH in activated microglia. (A) In unactivated microglia ClC-7 is degraded by a pathway involving proteasomes that appears similar to ERAD quality control mechanisms in other systems. This degradation may be due to poor assembly of ClC-7/Ostm1 heterodimers in the ER. (B) In an activated microglial cell, the Ostm1 protein is associated with ClC-7. This complex leads to an increase in ClC-7's proper assembly and efficient lysosomal targeting. The presence of ClC-7 in lysosomes results in a lowered pH and increased degradation of fAβ by these activated microglia.