Table 3.
Multivariate Cox model (overall survival)
| Hazard Ratio | 95% CI | P | |
|---|---|---|---|
| Best-fitted Cox model (n = 44a) | |||
| PROM expr > 1.32 (reference: PROM expr ≤1.32) | 4.56 | 1.27–16.40 | .008 |
| M stage M+ (reference: M0) | 3.20 | 1.27–8.10 | .012 |
| Saturated Cox model (n= 44a) | |||
| PROM expr > 1.32 (reference: PROM expr ≤1.32) | 4.93 | 1.32–18.38 | .008 |
| M stage, M+ (reference: M0) | 3.91 | 1.38–11.04 | .007 |
| Treatment HD (reference: SD) | 0.59 | 0.20–1.73 | .51 |
| Treatment NOR (reference: SD) | 1.25 | 0.32–4.88 | |
| Surgical resection, partial (reference: complete) | 1.44 | 0.46–4.50 | .54 |
| Best-fitted Cox model (nondesmoplastic; n = 38a) | |||
| PROM expr >1.32 (reference: PROM expr ≤1.32) | 3.78 | 1.07–13.37 | .020 |
| M stage, M+ (reference: M0) | 2.72 | 1.09–6.79 | .028 |
The Cox model demonstrates that PROM1 expression is an independent prognostic factor with regard to treatments, postsurgical tumor residue, and M stage. CI denotes confidence interval; PROM expr, PROM1 expression level; HD, high-dose chemotherapy (HDCT) followed by craniospinal irradiation; SD, standard dose chemotherapy plus radiotherapy; and NOR, chemotherapy or radiotherapy only.
aFor 1 patient, data were not available.