Table 1. Theoretical predictions of cortico-striatal synaptic plasticity dynamics as functions of pre-synaptic activity, post-synaptic activity, and dopamine concentration in comparison with the average experimental findings across studies on long-term effects in synaptic plasticity.
pre | post | dopa | theoretical predictions | theoretical prediction | experimental results |
0 | 0 | 0 | - | - | - |
1 | 0 | 0 | - | - | - |
0 | 1 | 0 | - | - | - |
0 | 0 | 1 | - | - | - |
1 | 1 | 0 | - | LTD | LTD (LTP) |
1 | 0 | 1 | LTDLTP | LTDLTP | - |
0 | 1 | 1 | - | - | - |
1 | 1 | 1 | LTDLTP | LTDLTP | LTDLTP |
The predictions are based on eq:value function weight update for and , corresponding to discount factors and , respectively; the experimental findings on [9]. A 1 in the first three columns denotes an active influence, whereas a 0 indicates that the corresponding activity is not involved in the synaptic changes. The symbol indicates that either LTD or LTP occurs depending on the concentration of dopamine; the symbol - denotes an absence of long-term changes in the synaptic weights.