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. 2011 May 12;7(5):e1001133. doi: 10.1371/journal.pcbi.1001133

Table 1. Theoretical predictions of cortico-striatal synaptic plasticity dynamics as functions of pre-synaptic activity, post-synaptic activity, and dopamine concentration in comparison with the average experimental findings across studies on long-term effects in synaptic plasticity.

pre post dopa theoretical predictions Inline graphic theoretical prediction Inline graphic experimental results
0 0 0 - - -
1 0 0 - - -
0 1 0 - - -
0 0 1 - - -
1 1 0 - LTD LTD (LTP)
1 0 1 LTDInline graphicLTP LTDInline graphicLTP -
0 1 1 - - -
1 1 1 LTDInline graphicLTP LTDInline graphicLTP LTDInline graphicLTP

The predictions are based on eq:value function weight update for Inline graphic and Inline graphic, corresponding to discount factors Inline graphic and Inline graphic, respectively; the experimental findings on [9]. A 1 in the first three columns denotes an active influence, whereas a 0 indicates that the corresponding activity is not involved in the synaptic changes. The symbol Inline graphic indicates that either LTD or LTP occurs depending on the concentration of dopamine; the symbol - denotes an absence of long-term changes in the synaptic weights.