Table 2. Genotype frequencies of CYP3A5, CYP2D6, CYP2B6, CYP2C9, CYP2C19 and ABCB1 between responder and nonresponder groups.
| Responders | Nonresponders | P | |
| N = 76 (%)a | N = 29 (%)a | ||
| CYP3A5 Genotype | 0.446 | ||
| *1/*1 | 1 (1) | 1 (3) | |
| *1/*3 | 11 (15) | 2 (7) | |
| *3/*3 | 64 (84) | 26 (90) | |
| CYP2D6 Genotype | 0.211 | ||
| *1/*1 | 4 (5) | 2 (7) | |
| *1/*2 | 12 (16) | 4 (14) | |
| *1/*3 | 2 (3) | 0 (-) | |
| *1/*4 | 16 (21) | 3 (10) | |
| *1/*5 | 1 (1) | 0 (-) | |
| *1/*6 | 1 (1) | 0 (-) | |
| *1/*9 | 2 (3) | 0 (-) | |
| *1/*10 | 2 (3) | 0 (-) | |
| *1/*41 | 1 (1) | 3 (10) | |
| *2/*2 | 6 (8) | 2 (7) | |
| *2/*3 | 1 (1) | 0 (-) | |
| *2/*4 | 9 (12) | 6 (21) | |
| *2/*5 | 1 (1) | 1 (3) | |
| *2/*6 | 1 (1) | 1 (3) | |
| *2/*9 | 2 (3) | 0 (-) | |
| *2/*35 | 1 (1) | 0 (-) | |
| *2/*41 | 1 (1) | 3 (10) | |
| *3/*17 | 1 (1) | 0 (-) | |
| *4/*4 | 2 (3) | 3 (10) | |
| *5/*41 | 2 (3) | 0 (-) | |
| *10/*41 | 1 (1) | 0 (-) | |
| *35/*35 | 1 (1) | 0 (-) | |
| *35/*41 | 0 (-) | 1 (3) | |
| *1/*2×3b | 3 (4) | 0 (-) | |
| *2/*2×3b | 2 (3) | 0 (-) | |
| CYP2B6 Genotypec | 0.751 | ||
| *1/*1 | 43 (57) | 18 (62) | |
| *1/*4 | 4 (5) | 0 (-) | |
| *1/*6 | 23 (30) | 9 (31) | |
| *4/*6 | 1 (1) | 0 (-) | |
| *6/*6 | 4 (5) | 1 (3) | |
| CYP2C9 Genotype | 0.425 | ||
| *1/*1 | 53 (70) | 19 (66) | |
| *1/*2 | 14 (18) | 7 (24) | |
| *1/*3 | 6 (8) | 2 (7) | |
| *2/*2 | 0 (-) | 1 (3) | |
| *2/*3 | 2 (3) | 0 (-) | |
| *3/*3 | 1 (1) | 0 (-) | |
| CYP2C19 Genotype | 0.260 | ||
| *1/*1 | 54 (71) | 19 (66) | |
| *1/*2 | 22 (29) | 9 (31) | |
| *2/*2 | 0 (-) | 1 (3) | |
| ABCB1 genotype (C3435T) | 0.266 | ||
| C/C | 24 (32) | 14 (48) | |
| C/T | 39 (51) | 12 (41) | |
| T/T | 13 (17) | 3 (10) |
a
Discrepancies in total numbers correspond to genotyping missing data.
b
Patients with 3 functional alleles of CYP2D6.
c
Non available data on SNP/genotype in two subjects (1 Responder and 1 Nonresponder) due to methodological problems.