Table 3. Phenotype frequencies of CYP3A5, CYP2D6, CYP2B6, CYP2C9, CYP2C19 and ABCB1 between responder and nonresponder groups.
| Responders | Nonresponders | Pb | |
| N = 76 (%)a | N = 29 (%)a | ||
| CYP3A5 Phenotype | 1.000 | ||
| Extensive (*1/*1 1/*3) | 12 (16) | 3 (10) | |
| Poor (*3/*3) | 64 (84) | 26 (90) | |
| CYP2D6 Phenotype | 0.032 | ||
| Extensive (*1,*2, *3, *6, *35) | 64 (84) | 26 (90) | |
| Ultrarapid (*1xN, *2xN) | 5 (7) | 0 (0) | |
| Intermediate (*9*10,*41) | 5 (7) | 0 (0) | |
| Poor (*4/*4) | 2 (3) | 3 (10) | |
| CYP2B6 Phenotype | 0,639 | ||
| Extensive (*1/*1) | 43 (57) | 18 (62) | |
| Poor (*6) | 27 (36) | 10 (35) | |
| Ultrarapid (*4) | 4 (5) | 0 (-) | |
| CYP2C9 Phenotype | 0.779 | ||
| Extensive (*1/*1, *1/*2) | 67 (88) | 26 (90) | |
| Intermediate (*1/*3) | 6 (8) | 2 (7) | |
| Poor (*2, *3) | 3 (4) | 1 (3) | |
| CYP2C19 Phenotype | 0.260 | ||
| Extensive (*1/*1) | 54 (71) | 19 (66) | |
| Intermediate (*1/*2) | 22 (29) | 9 (31) | |
| Poor (*2/*2) | 0 (-) | 1 (3) | |
| ABCB1 Phenotype (C3435T) | 0.266 | ||
| Extensive (C/C) | 24 (32) | 14 (48) | |
| Intermediate (C/T) | 39 (51) | 12 (41) | |
| Poor (T/T) | 13 (17) | 3 (10) |
a
Discrepancies in total numbers correspond to genotyping missing data.
b
Bold numbers indicate statistically significant differences between patients.
c
Non available data on SNP/genotype in two subjects (1 Responder and 1 Nonresponder) due to methodological problems. One patient showed *4/*6 genotype with unknown clinical significance, therefore it was not considered in phenotype analysis.