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. 2011 May 12;6(5):e19785. doi: 10.1371/journal.pone.0019785

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A. Decreased oxidative DNA damage as measured by 8-oxoG (pg/µg genomic DNA) ELISA in polyp-free segments of intestine from 10% compared to 21% oxygen APC^Min/+ mice. Data shown as mean ± SEM, with n = 3. B. Decreased DNA damage response observed by γ-H2AX western blotting in polyp-free intestine of 10% compared to 21% oxygen APC^Min/+ mice. Relative intensity quantified by densitometric scanning of γ-H2AX normalized to β-actin protein (graph), n = 3. C. Decreased protein levels of β-catenin and its transcriptional target cyclin D1 in polyp-free intestine of 10% compared to 21% oxygen APC^Min/+ mice. Representative samples in each oxygen condition and β-actin serves as protein loading control, n = 3.