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Hyperbilirubinemia caused by mutations of Atp11c. Plasma pigmentation (A) and its relationship with B-cell lymphopenia (B) in Atp11c mutant mice. (C) Allelism testing of emptyhive and spelling alleles of Atp11c. (D) Quantitation of total and direct bilirubin in plasma, and the severity of plasma hyperbilirubinemia and pigmentation across various ages (E). Error bars in C and D represent SEM. Data are representative of at least three independent experiments.
