Fig. 4.

Atp11c mutant mice are cholestatic. (A) LC/MS ion intensity profile for the 1039.625s retention group. The ion at 373.289 (m/z) showed the greatest mean difference between Atp11c mutant (n = 3) and littermate control (n = 4) serum. Hypothetical ion identities are shown in parentheses below each m/z value, which are all consistent with the chemical structure and molecular weight of cholic acid (B). (C) Total bile acids as measured from the plasma of Atp11c mutant and littermate control mice. Error bars in A and C represent SEM.