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Blocking CD40L only partially inhibits the RF B-cell response to IgG2a antichromatin Abs. BALB/c mice were killed on day 5 after cell transfer with CD40L blocking and PL2-3 as indicated. (A) 4–44+ surface and intracellular double-positive cells. (B) Fraction of 4–44+ cells that had lost expression of IgD. (C and D) Splenic 4–44+ AFCs of IgM (C) or IgG2a (D) isotype. Data are compiled from three independent experiments. *P < 0.05 and **P < 0.01, Mann-Whitney two-tailed test.
