Figure 5.

Protein-protein interactions via the quantitative Le Chatelier's theorem. Shown is the covariance matrix as a heat map for the single cell, n = 1 data (left) and the resolution of the matrix into the two most important tiers (right). Note the strong correlation of MIF and of IL-8 with the other proteins. Red implies inhibition and blue implies activation. The range is [−4e + 11, 4e + 11] for the covariance matrix shown in the left panel. This range is chosen to attenuate the high reading of the self-correlations in the covariance matrix. This heat map also provides a graphic representation of the protein interaction network. The range shown on the right hand side is respectively top [−1.5e12, 1.5e12] and bottom [−2.9e10, 2.9e10].