Table 4.
Results of meta-analyses for resection margin status, recurrence rate and survival after laparoscopic liver resection (LLR) vs. open liver resction (OLR) for cases of malignant disease
| Pathological and oncological outcomes | Number of studies | Patients | Lap/Open | SMD/OR (95% CI) | P-value | Study heterogeneity | |||
|---|---|---|---|---|---|---|---|---|---|
| I2 | Q | DF | P-value | ||||||
| Studies comparing resection margin status for LLR vs. OLR for all types of malignant disease | |||||||||
| Resection margin (mm) | 8 | 392 | 215/177 | −0.356 (−1.061, 0.349)a | 0.318 | 89.9% | 69.41 | 7 | <0.0001 |
| Resection margin <1 cm | 6 | 351 | 138/213 | 0.511 (0.293, 0.893)b | 0.030 | 13.5% | 5.77 | 5 | 0.328 |
| Resection margin positive | 8 | 591 | 250/341 | 0.524 (0.296, 0.927)b | 0.026 | 0.00 | 5.56 | 7 | 0.591 |
| Studies comparing long-term outcome with LLR vs. OLR for HCC only | |||||||||
| Hepatic recurrence rate | 4 | 366 | 129/237 | 0.832 (0.527, 1.314)b | 0.430 | 0.00 | 0.64 | 3 | 0.887 |
| Disease-free survival | 6 | 424 | 166/258 | 0.990 (0.605, 1.621)b | 0.969 | 0.00 | 1.88 | 5 | 0.864 |
| Overall survival | 7 | 500 | 186/314 | 1.500 (1.002, 2.246)b | 0.049 | 0.00 | 3.62 | 6 | 0.728 |
Lap, laparoscopic; SMD, standardized mean difference; OR, odds ratio; I2, index used to measure the extent of study heterogeneity in meta-analysis; Q, statistic used to assess for study heterogeneity in meta-analysis; DF, degrees of freedom.
a
SMD with 95% CI.
b
OR with 95% CI.